General Research

These pages are for medical professionals to bring the abstract studies and any research on Lyme to one local place to make it easier to find important information pertaining to Lyme. Please note this may include any one of the over 300 chronic diseases that Lyme “mimics” and how it or they relate to Lyme.

http://www.ncbi.nlm.nih.gov/pubmed/8497409?dopt=AbstractPlus
“The background to the discovery of Lyme disease teaches a salutary lesson. The symptoms and signs of this disease had been observed by doctors for a century, particularly in the Scandinavian countries, without anybody being able to draw the right conclusions. The first patients were identified in the USA by their relatives or by themselves. Recognition of their plight by the medical profession was chiefly due to the patients’ tenacity. We must remember to pay attention to what patients tell us; they may often be right, even when they seem to be wrong. Where fact and theory are incompatible, it is theory, not fact, that needs to be amended. In all likelihood, we all from time to time observe disorders in our patients that are inconsistent with established scientific models, but which we nevertheless attempt to squeeze into these models. Such an approach is not uncommon in the history of medicine. The message from Lyme calls for humility and reflexion.”

DIAGNOSING CHALLENGES OF EARLY LYME DISEASE:

Interlaboratory comparison of test results for detection of Lyme disease by 516 participants in the Wisconsin State Laboratory of Hygiene/College of American Pathologists Proficiency Testing Program.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC229622/

Diagnostic challenges of early Lyme disease: Lessons from a community case series
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698836/#B9

https://peerj.com/articles/322.pdf

All physicians should be aware that it is now known that a chronic illness or disease is caused by a chronic infection or at least attributed by a chronic infection. (http://articles.mercola.com/sites/articles/archive/2012/02/05/dr-dietrich-klinghardt-on-lyme-disease.aspx) We do have confirmation from several physicians that physicians are being told this at medical conferences. It is not always Lyme Disease which makes diagnosing Lyme Disease even more complicated. In dealing with a chronic condition even if it’s just a chronic headache, if a cause cannot be found… think infection! We should note that borrelia is not listed on some of the diseases on the link below and borrelia should be.
http://en.wikipedia.org/wiki/List_of_human_diseases_associated_with_infectious_pathogens

IDSA LYME DISEASE GUIDELINES ARE FLAWED:

Change IDSA guidelines by Dr. Volkman

The Infectious Diseases Society of America Lyme guidelines: a cautionary tale about the development of clinical practice guidelines
http://www.peh-med.com/content/5/1/9/abstract

LYME DISEASE IS IN KENTUCKY:

The Lyme Disease Spirochete, Borrelia burgdorferi, in Tick Species Collected from Raccoons (Procyon lotor) and Opossums (Didelphis virginiana) Trapped in the Warren and Barren Counties of South Central Kentucky
http://digitalcommons.wku.edu/theses/118/
PDF VERSION: http://digitalcommons.wku.edu/cgi/viewcontent.cgi?article=1118&context=theses

Lyme Disease Risk Assessment No. 16-61-A2WW-94, Fort Knox, Kentucky, 20-21 November 1993
US ARMY Fort Knox

LYME DISEASE IS IN THE SOUTH

Lyme borreliosis in human patients in Florida and Georgia, USA.             http://www.ncbi.nlm.nih.gov/pubmed/23781138

Geographical and genospecies distribution of Borrelia burgdorferi sensu lato DNA detected in humans in the USA.
http://www.ncbi.nlm.nih.gov/pubmed/24568883

Ixodes affinis (Acari: Ixodidae) in southeastern Virginia and implications for the spread of Borrelia burgdorferi, the agent of Lyme disease
http://onlinelibrary.wiley.com/doi/10.1111/j.1948-7134.2011.00191.x/abstract

Ixodes affinis in Southeastern Virginia and in Southeastern Virginia and Implications for the Spread of Implications for the Spread of Borrelia burgdorferi, Borreliaburgdorferi, the Agent of Lyme Disease the Agent of Lyme Disease
http://www.mosquito-va.org/pdfs/2012%20Presentations/7%20-%20RMN_VCMA_2012.pdf

 

LONG-TERM ANTIBIOTIC THERAPY:

Counterpoint: Long-Term Antibiotic Therapy Improves Persistent Symptoms Associated with Lyme Disease
http://m.cid.oxfordjournals.org/content/45/2/149.long

The Antibiotics Doxycycline and Minocycline Inhibit
the Inflammatory Responses to the Lyme Disease
Spirochete Borrelia burgdorfer
J Infect Dis.-2009-Bernardino-1379-88

SEROLOGIC TESTS:

Decreased CD57 lymphocyte subset in patients with chronic Lyme disease.
http://www.ncbi.nlm.nih.gov/pubmed/11222912

National surveillance case definition & diagnostic tests
ALFONSE DAMATO – CDC LETTER 12-23-96-1

Serologic tests need to be combined with clinical signs and symptoms.
http://www.ncbi.nlm.nih.gov/pubmed/21978712

Testimony by Paul Mead, MD, MPH, Medical Epidemiologist with the CDC
2004.01.29 Testimony by Paul Mead
(via http://www.hhs.gov/asl/testify/t040129.html)

Lyme borreliosis–problems of serological diagnosis.
http://www.ncbi.nlm.nih.gov/pubmed/9007597

“Confirmatory testing in early Lyme disease continues to be problematic for community clinicians.”
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698836/#B9

DNA Sequencing Diagnosis of Off-Season Spirochetemia with Low Bacterial Density in Borrelia burgdorferi and Borrelia miyamotoi Infections
http://www.mdpi.com/1422-0067/15/7/11364

Rocky Mountain Spotted Fever Tests

Inadequacy of IgM Antibody Tests for Diagnosis of Rocky Mountain Spotted Fever.
http://www.ncbi.nlm.nih.gov/pubmed/25092818

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The hypothesis of trans-oceanic migration of Borrelia species.
http://www.ncbi.nlm.nih.gov/pubmed/23263953

Exotic ticks introduced into the United States on imported reptiles from 1962 to 2001 and their potential roles in international dissemination of diseases.
http://www.ncbi.nlm.nih.gov/pubmed/12719143

Characterization of Biofilm Formation by Borrelia burgdorferi In Vitro
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0048277

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CHRONIC LYME PERSISTS AFTER SHORT TERM TREATMENT:

Persistence of Lyme Disease
Persistence of Lyme Disease-273 Peer-Reviewed Studies

Persistence of Lyme Disease Despite Antibiotic Treatment
77 Peer-Reviewed Studies, 1977-2012
LDPersist77studies

Proof That Chronic Lyme Disease Exists
http://www.hindawi.com/journals/ipid/2010/876450/

Persistence of Borrelia burgdorferi in Rhesus Macaques following Antibiotic Treatment of Disseminated Infection
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0029914

Chronic neurologic manifestations of Lyme disease
http://www.ncbi.nlm.nih.gov/pubmed/2172819

Review of evidence for immune evasion and persistent infection in Lyme disease
IJGM-44114-review-of-evidence-for-immune-evasion-and-persistent-infecti_042213-2

Resurgence of Persisting Non-Cultivable Borrelia burgdorferi following Antibiotic Treatment in Mice                                                                                                                                  http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0086907#pone.0086907-Battafarano1

Spirochetes present in Total HIP Joint Replacement tissues
http://www.lymeneteurope.org/forum/viewtopic.php?f=6&t=3987

Neurologic complications of Lyme disease.
http://www.ncbi.nlm.nih.gov/pubmed/8265833?dopt=Citation

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Knowledge of Tick-Borne Illnesses

Preventive Behaviors and Knowledge of Tick-Borne Illnesses: Results of a Survey From an Endemic Area
http://journals.lww.com/jphmp/pages/articleviewer.aspx?year=9000&issue=00000&article=99836&type=abstract

Lyme disease diagnosis and treatment: lessons from the AIDS epidemic.
http://www.ncbi.nlm.nih.gov/pubmed/21196901

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Lab Comparisons

A comparison of Lyme disease serologic test results from four laboratories in patients with persistent symptoms after antibiotic treatment
http://cid.oxfordjournals.org/content/early/2014/09/02/cid.ciu703

Gluten Sensitivity

 

Small Amounts of Gluten in Subjects with Suspected Nonceliac Gluten Sensitivity: a Randomized, Double-Blind, Placebo-Controlled, Cross-Over Trial.
http://www.ncbi.nlm.nih.gov/pubmed/25701700


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